Ghana and Portugal also look capable in one of the most difficult groups to call.
Diego Alonso has a wealth of options up top, with Darwin Nunez representing a changing of the guard as Luis Suarez and Edinson Cavani enter the final stages of their careers.
While Federico Valverde could be one of the stars of the tournament having emerged as a key piece for Real Madrid in recent years.
Here’s everything you need to know about the Group H match at Education City Stadium in Al Rayyan:
When is it?
Uruguay vs South Korea kicks off at 1pm GMT on Thursday 24 November, 2022.
The match will be played at Education City Stadium in Al Rayyan.
How can I watch it?
The game will air live on BBC One, and it will also stream live online through the BBC iPlayer. Coverage starts at 12:45pm.
Meanwhile, The Independent will provide live match updates here.
What was the team news?
Luis Suarez is enjoying a fine spell for Nacional and could join Darwin Nunez up top, meaning Edinson Cavani will share 90 minutes with the former Liverpool and Barcelona striker.
Nunez limped out of training this week with an ankle problem, but he did return and should be good to go.
Diego Godin is also pushing to start, although Barcelona center-back Ronald Araujo, injured since late September, is likely to be out until at least the knock-out stages.
Son Heung-min is in contention to start, after recovering from a fracture to the face, and the Spurs star will be in a mask if he plays.
Paulo Bento is also hoping Kim Jin-su, nursing a hamstring problem, can be available, but this game should come too soon.
Uruguay XI: Rochet; Varela, Godin, Gimenez, Olivera; Bentancur, Valverde, Vecino; Pellistri, Suarez, Nunez
South Korea XI: Kim Seung-gyu; Yoon Jong-gyu, Kim Min-jae, Kim Young-gwon, Kim Jin-su; Jung Woo-young, Hwang In-beom, Kwon Chang-hoon; Hwang Hee-chan, Hwang Ui-jo, Son Heung-min
Uruguay – 8/11
Draw – 5/2
South Korea – 9/2
With Son rusty, Uruguay can grab the points here, with Darwin Nunez capturing some impressive form just in time to emerge as La Celeste’s present and future, even with Edinson Cavani and Luis Suarez still able to contribute. 2-1 to Uruguay.